Neuraé is a new skincare line developed by Sisley Group Laboratories that combines neuroscience and cosmetics. By targeting the connection between skin and emotions, Neuraé offers visible results while supporting overall well-being. Its formulas are based on over ten years of scientific research and focus on restoring balance, radiance, and calm to the skin through a unique combination of active ingredients, textures and scents.
Our emotions form an intrinsic link between our skin and brain
This discovery is the foundation of a unique scientific approach to beauty. It opens up a new path that nurtures skin health in harmony with emotional well-being. Neuraé is the result of over ten years of research conducted by Sisley Group Laboratories. The name itself is meaningful: “neur” is derived from the Greek word neuron, meaning sinew, cord or nerve, referring to the nervous system and the brain. “Aé” stands for being activated by emotions. With Neuraé, the science of emotions is channeled into visibly enhancing the skin, for results you can both see and feel.
Our emotions transform our face
The way we live and experience emotions—physically, cognitively and behaviorally—plays a major role in how our skin and facial expressions evolve. These repeated emotional moments naturally activate or relax specific facial muscles, forming what are universally recognized as emotional expressions. Over time, this repetition shapes our skin with visible lines such as laughter lines, frown lines, tear troughs and stress creases.
We have identified the three most common types of expression
Our facial expressions reflect our emotional state. When certain emotions are felt repeatedly, they begin to disrupt the harmony of our features. The skin, as the most visible part of ourselves, reveals the toll of time and emotion. Neuraé addresses three major emotional expressions that visibly impact the skin. Tiredness leads to a loss of firmness, weakened muscle tone, a drawn appearance, puffiness and sagging features like drooping eyelids and nasolabial folds. Sadness causes the skin to lose its natural radiance, resulting in a dull complexion and downturned lines. Stress creates tension in the face, fine lines, brow creases and premature wrinkles.
Skin and brain: a special connection
This connection begins in the early stages of life. On the 21st day of embryonic development, the outermost layer of cells—the ectoderm—gives rise to both the nervous system and the skin. This shared origin explains the biological similarities between neurons and skin cells. Throughout life, the brain and skin remain in constant communication, exchanging signals in both directions.
Neuromediators are the words our skin and brain use to communicate
This communication happens through neuromediators, the chemical messengers that shape both skin response and emotional experience. There are more than 40 known neuromediators, and Sisley Laboratories has identified four that are key to this skin-brain dialogue. Beta-endorphin, the pleasure molecule, promotes feelings of well-being in the brain and supports skin healing while reducing inflammation. GABA helps calm the brain by lowering stress and anxiety; in the skin, it soothes and aids repair. Cortisol, known as the stress hormone, increases anxiety in the brain and compromises the skin’s barrier function. CGRP, the pain messenger, heightens inflammation and reduces the pain threshold when levels are too high in both brain and skin. Neuraé works to restore emotional balance by enhancing positive signals and calming negative ones, improving both skin and spirit.
Skincare takes on a new dimension through our emotions
By targeting the neuromediators responsible for this dialogue, Neuraé enhances skin function and emotional well-being. Through this approach, skincare evolves beyond surface treatment to harmonize the deeper exchange between the skin and the mind. It provides powerful tools to reduce the visible impact of stress and time by fostering a positive rhythm between our inner and outer selves.
With Neuraé
Neuraé offers a groundbreaking solution to skin that looks dull, tired or stressed. It restores balance and promotes facial harmony using an intelligent blend of products. The Neuraé collection includes a serum, three creams and three aromatic boosters, each designed to target the skin’s response to fatigue, sadness or stress. The énergie routine firms and energises tired skin, joie restores radiance and glow, and sérénité soothes and smooths skin under stress. These products are enriched with neuro-actives, neuro-fragrances and neuro-textures to support skin harmony and emotional balance — delivering results you can see and feel.
Neuraé and the power of nature
Each formula is crafted to support both skin health and emotional harmony. Composed of at least 95% naturally derived ingredients, Neuraé products rely on traceable botanicals and sustainably harvested byproducts. Plant actives are extracted using environmentally conscious techniques and selected not just for their skincare benefits but for their positive influence on mood and emotional states.
We believe in a virtuous science
Performance remains at the heart of every Neuraé formula. Sisley Laboratories, renowned for their deep expertise in skin physiology, have developed advanced products that go beyond standard active ingredients. Neuraé represents a new generation of science-led skincare—intelligent, effective and emotionally aware.
NA3 technology
At the core of every Neuraé product lies the proprietary NA3 technology, which combines three pillars: neuro-actives, neuro-fragrances, and neuro-textures. Neuro-actives are high-performance botanical extracts designed to send positive messages to the skin while reducing negative ones. Red indigo stimulates beta-endorphin and limits cortisol production. Scutellaria from the Alps enhances beta-endorphin and GABA activity. Epurea extract helps limit CGRP, reducing visible tension and promoting relaxation. The resurrection plant helps reduce cortisol levels. Neuro-fragrances are created based on olfactotherapy principles. Each of the four scents was selected for its ability to trigger emotional responses. These were validated using EEG (electroencephalography) to measure their impact on mood and brain activity. Neuro-textures are designed to evoke emotion through touch. Tested using implicit response time analysis, each texture elicits a specific emotional reaction. The signature oil and serum in each routine are built on this sensorial science, combining neuro-actives in a patented blend.
Unprecedented, evidence-based tests devised by our research teams
What began as a hypothesis—that neuromodulating ingredients could influence both mind and skin—was proven through extensive testing. In collaboration with external experts, Sisley Laboratories developed a new testing protocol. The results exceeded expectations: not only were the benefits confirmed, but an additional effect was observed. Neuromodulators were shown to extend neural projection under both chronic and acute stress. In short, communication between skin and brain improves—even as we age.
Cells
Sisley’s cellular biology lab worked with neurodermatology experts to develop a unique testing method inspired by the 2012 Nobel Prize-winning hiPS (human-induced pluripotent stem cells). This technology allowed researchers to co-culture human neurons and skin cells, simulating more realistic skin-brain interactions. With this method, they measured the increase in neural projection, neuromediator signaling and receptor activity under stress and during treatment with Neuraé ingredients.
Skin
More than 200 participants took part in clinical skin studies. These trials included ELISA-based neuromediator measurements, corneometry for hydration, tewametry for skin protection, colorface imaging for radiance and cutometry for firmness. Each Neuraé product was evaluated for specific benefits, including smoother texture, better tone and reduced signs of fatigue. Self-evaluations also confirmed improvement in skin comfort and quality.
Emotions
Emotional trials included 180 participants and were designed to measure both physiological and psychological responses. Heart rhythm and facial expressions were monitored for signs of joy, calm or stress relief. Implicit association tests and questionnaires were used to assess the subconscious and conscious emotional impact of each product. Results confirmed significant increases in emotional well-being and mood stability.
Neuraé reframes cosmetics through the lens of neuroscience, for results you can see and feel
Healthy skin is deeply connected to emotional well-being. That’s why Neuraé was created—not only to take care of skin, but to care for people and the planet. All Neuraé products are designed to deliver maximum efficacy with minimal environmental and social impact. The main logistics center meets high sustainability standards and features a rooftop solar system. All production sites treat 100% of wastewater. Based in France, the company actively tracks its carbon emissions to reduce its ecological footprint. Creams come in refillable glass jars with recyclable plastic refills. Packaging uses responsibly sourced materials like wood, recycled paper, and 15% recycled glass.
Driven by emotional intelligence
Neuraé is founded on a celebration of positive emotions—the ones we sometimes suppress in our hectic lives. By identifying and supporting these feelings, Neuraé encourages their repetition and longevity. The brand believes that science and emotion can coexist. That progress and individuality can be reconciled. And that technology can serve our deepest needs. For this reason, 1% of all profits are donated to charities that support mental well-being.
